Accès privé

Roger LE GRANDRoger Le Grand has been head of IMmunology of Viral and Auto-immune diseases department since 2015, and formerly the Department of Immuno-virology (SIV) since 2008. He is the IDMIT, infrastructure for Infectious Diseases Models and innovative Therapies, chief executive since 2012.

Dr. Le Grand’s research group is currently developing NHP models for HIV, HBV, dengue, human influenza, Chikungunya, Chlamydia, Pertussis and new emerging diseases. Dr Le Grand is particularly interested in host-pathogen interactions and the prevention of viral transmission.

His researches have generated more than 150 referenced peer-reviewed publications. He has been working as an expert for several French national research agencies, the French government, the European TRANSVAC program, the Bill and Melinda Gates Foundation and the WHO.

The goal of his research is to study host response to infections with the aim to understand basic mechanisms of immunology and develop new prevention strategies of human infectious diseases. His work is mainly based on the use of preclinical models, including non-human primate models of human diseases, and the development of advanced technologies in cytometry and in vivo imaging, with a continuing effort to translate findings in experimental models to the clinical practice.

Roger Le Grand is PI in the Correlates of Protection division of the VRI

Selected publications

[1] Bernard-Stoecklin S, Gommet C, Corneau AB, Guenounou S, Torres C, Dejucq-Rainsford N, Cosma A, Dereuddre-Bosquet N and Le Grand R. Semen CD4+ T cells and macrophages are productively infected at all stages of SIV infection in macaques. PLoS Pathogens 2013; 9(12):e1003810.
[2] Bruel T, Dupuy S, Demoulins T, Rogez-Kreuz C, Dutrieux J, Corneau A, Cosma A, Cheynier R, Dereuddre-Bosquet N, Le Grand R and Vaslin B. Plasmacytoid dendritic cell dynamics tune interferon-alfa production in SIV-infected cynomolgus macaques. PLoS Pathogens 2014; 10(1):e1003915.
[3] Damouche A, Lazure T, Avettand-Fenoel V, Huot N, Dejucq-Rainsford N, Satie AP, Melard A, David L, Gommet C, Ghosn J, Noel N, Pourcher G, Martinez V, Benoist S, Bereziat V, Cosma A, Favier B, Vaslin B, Rouzioux C, Capeau J, Muller-Trutwin M, Dereuddre-Bosquet N, Le Grand R, Lambotte O and Bourgeois C. Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection. PLoS Pathogens 2015; 11(9):e1005153.
[4] Epaulard O, Adam L, Poux C, Zurawski G, Salabert N, Rosenbaum P, Dereuddre-Bosquet N, Zurawski S, Flamar AL, Oh S, Romain G, Chapon C, Banchereau J, Levy Y, Le Grand R and Martinon F. Macrophage- and Neutrophil-Derived TNF-alpha Instructs Skin Langerhans Cells To Prime Antiviral Immune Responses. Journal of immunology; 2014, 193(5):2416-2426.
[5] Le Grand R, Bosquet N, Dispinseri S, Gosse L, Desjardins D, Shen X, Tolazzi M, Ochsenbauer C, Saidi H, Tomaras G, Prague M, Barnett SW, Thiebaut R, Cope A, Scarlatti G and Shattock RJ. Superior efficacy of an HIV vaccine combined with ARV prevention in SHIV challenged non-human primates. Journal of Virology 2016; 90(11):5315-28.
[6] Li D, Romain G, Flamar AL, Duluc D, Dullaers M, Li XH, Zurawski S, Bosquet N, Palucka AK, Le Grand R, O'Garra A, Zurawski G, Banchereau J and Oh S. Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. Journal of Experimental Medicine 2012; 209(1):109-121.
[7] Moog C, Dereuddre-Bosquet N, Teillaud JL, Biedma ME, Holl V, Van Ham G, Heyndrickx L, Van Dorsselaer A, Katinger D, Vcelar B, Zolla-Pazner S, Mangeot I, Kelly C, Shattock RJ and Le Grand R. Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques. Mucosal Immunology 2014; 7(1):46-56.
[8] Romain G, van Gulck E, Epaulard O, Oh S, Li D, Zurawski G, Zurawski S, Cosma A, Adam L, Chapon C, Todorova B, Banchereau J, Dereuddre-Bosquet N, Vanham G, Le Grand R and Martinon F. CD34-derived dendritic cells transfected ex vivo with HIV-Gag mRNA induce polyfunctional T-cell responses in nonhuman primates. European journal of immunology 2012; 42(8):2019-2030.
[9] Salabert N, Todorova B, Martinon F, Boisgard R, Zurawski G, Zurawski S, Dereuddre-Bosquet N, Cosma A, Kortulewski T, Banchereau J, Levy Y, Le Grand R and Chapon C. Intradermal injection of an anti-Langerin-HIVGag fusion vaccine targets epidermal Langerhans cells in nonhuman primates and can be tracked in vivo. European journal of immunology 2016; 46(3):689-700.
[10] Skold AE, Hasan M, Vargas L, Saidi H, Bosquet N, Le Grand R, Smith CI and Spetz AL. Single-stranded DNA oligonucleotides inhibit TLR3-mediated responses in human monocyte-derived dendritic cells and in vivo in cynomolgus macaques. Blood 2012; 120(4):768-777.